Malaria continues to be a significant global health issue, with the World Health Organization reporting 282 million cases and 610,000 deaths across 80 countries. The urgency for effective prevention methods has led to increased focus on vaccinations. Current vaccines like RTS-S (Mosquirix) and R21/Matrix-M have shown efficacy in reducing clinical cases, especially in high-transmission regions. Dr. Neha Rastogi, a senior consultant in infectious diseases, emphasizes the importance of vaccination in providing partial immunity, particularly for vulnerable populations such as young children and pregnant women. Despite the promising results, India does not currently incorporate malaria vaccines into its Universal Immunisation Programme, relying instead on mosquito control and early treatment strategies. The World Malaria Report 2024 highlights that existing methods are not sufficient to eliminate the disease, underscoring the need for a holistic approach that includes vaccination. Challenges such as accessibility, costs, and the requirement for multiple doses pose barriers to effective vaccination in high-risk areas. However, the integration of vaccines into malaria prevention strategies could significantly reduce disease severity and mortality, making them a vital component in the fight against malaria.