In vitro fertilization (IVF) is a common fertility treatment, but many couples experience failures due to overlooked male factors. Research indicates that male infertility contributes to 49% of cases, yet the focus often remains on female-related issues. Dr. Pallavi Prasad, a fertility specialist in Bengaluru, highlights the importance of assessing sperm health, particularly sperm DNA integrity. Damage to sperm DNA can lead to poor embryo development and miscarriage, a phenomenon known as sperm DNA fragmentation. Various lifestyle factors, including stress, smoking, and exposure to heat, can exacerbate this issue. Furthermore, conditions like varicocele and hormonal imbalances can further impair sperm function. While IVF techniques like ICSI can assist with sperm motility and count, they do not rectify DNA damage. Advanced testing methods can identify sperm DNA fragmentation and oxidative stress markers, allowing for early intervention. Studies show that addressing these male factors can significantly improve embryo development and implantation rates, ultimately enhancing the likelihood of successful pregnancies. Recognizing the male factor in infertility is crucial for effective fertility care, ensuring both partners are evaluated for optimal outcomes.