Roaming cats can be a source of zoonotic pathogens, which are capable of infecting both animals and humans. Research indicates that outdoor-roaming cats have three to five times the likelihood of carrying these pathogens compared to indoor cats. This risk is exacerbated by the fact that about 60% of owned cats have unsupervised outdoor access, leading to potential interactions with wildlife and contamination of shared spaces. Cats can bring home pathogens from prey such as rodents and birds, creating a pathway for diseases like rabies and Toxoplasma gondii. To combat these risks, experts recommend preventing unsupervised roaming by providing contained outdoor access options like catios or leashed walks. Regular veterinary care, including vaccinations and treatment for parasitic infections, is also essential. The article emphasizes that responsible management of pet cats can safeguard public health, feline welfare, and biodiversity, aligning with the One Health approach, which focuses on the interconnectedness of human, animal, and environmental health.