Marty Makary has resigned as Commissioner of the U.S. Food and Drug Administration (FDA) following a contentious disagreement with the Trump administration regarding the approval of flavored e-cigarettes. His resignation, which took place on Tuesday, was prompted by his belief that these products pose a significant risk to young people due to their appealing flavors and addictive nicotine content. Despite his objections, the administration moved forward with the authorization, leading to increased internal pressure and tension within the agency. Makary's tenure was marked by broader conflicts over regulatory policies, including drug approvals and vaccine guidelines, which put him at odds with various stakeholders. Following his departure, President Donald Trump acknowledged Makary's contributions, stating he would lead a good life ahead. In the interim, Kyle Diamantas has been appointed as acting commissioner while the FDA seeks a permanent replacement.