Oral steroids, including Prednisone and Dexamethasone, are powerful anti-inflammatory drugs that suppress the immune system, typically prescribed for severe conditions like asthma exacerbations and autoimmune diseases. In contrast, painkillers such as Paracetamol, Ibuprofen, and Diclofenac primarily relieve pain and fever, with some offering mild anti-inflammatory effects. Misuse of oral steroids is a growing concern in India, where they are often taken without medical supervision for quick relief or bodybuilding purposes. This misuse can lead to serious long-term health issues, including Type 2 Diabetes, weight gain, and osteoporosis. Special caution is advised for individuals with diabetes, hypertension, or older age, as they are more susceptible to steroid-related complications. It is crucial to differentiate between the two classes of drugs: painkillers for everyday symptoms and steroids for serious inflammatory conditions. Self-medication with steroids can be harmful, emphasizing the need for professional medical advice.