Sheriff Chris Nanos, leading the investigation into Nancy Guthrie's disappearance from Tucson, Arizona, stated that investigators quickly suspected foul play after her initial report. On February 1, authorities received a call regarding the 84-year-old woman's absence, and Nanos noted that the scene prompted homicide investigators to be involved immediately due to their role in missing persons cases. The investigation has since expanded to include multiple agencies, including the Federal Bureau of Investigation (FBI). Currently, investigators are focusing on DNA evidence, with labs exploring various avenues to analyze the collected samples. Savannah Guthrie, a host on the 'Today' show, along with her siblings, has made emotional public appeals for information, emphasizing their commitment to finding their mother. The FBI has offered a reward of $100,000 for tips leading to Nancy's return, while the Guthrie family has announced a $1 million reward related to the case. Anyone with information is urged to contact the FBI or the Pima County Sheriff's Department.