UCF's Innovative Exosome Technology Offers Hope for Cancer and Heart Disease Treatment
UCF Researcher Develops “Smart, Tiny Bubbles” to Treat Cancer and Heart Disease

Image: University Of Central Florida
Dinender Singla, a researcher at the University of Central Florida (UCF), has developed a groundbreaking exosome-based delivery system that targets cancer and heart disease treatments. This technology aims to deliver therapeutics precisely where needed, potentially reducing side effects and improving outcomes for patients. The project is now moving towards clinical trials with the support of investor Chakri Toleti.
- 01The technology uses exosomes, which are tiny vesicles secreted by cells, to deliver targeted therapies for heart disease and cancer.
- 02Singla's research focuses on treating triple-negative breast cancer, which has a low five-year survival rate of 77%-78%.
- 03The partnership with Chakri Toleti aims to accelerate the manufacturing and clinical trial process for the new therapy.
- 04Exosome therapy has shown promise in killing cancer cells at lower doses than traditional chemotherapy while protecting heart health.
- 05The project is part of UCF's initiative to foster public-private partnerships that translate research into real-world medical applications.
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Dinender Singla, a professor at the University of Central Florida (UCF), has developed a novel technology that utilizes exosomes—tiny cell-derived vesicles—to deliver targeted treatments for cancer and heart disease. This innovative system encapsulates drugs within exosomes and coats them with specific markers to direct them to precise areas in the body, enhancing treatment efficacy while minimizing side effects. Singla’s research is particularly focused on addressing heart damage caused by cancer therapies, such as chemotherapy and radiation, which can lead to inflammation and further complications. The technology has shown promising results in laboratory settings, especially against triple-negative breast cancer, which has a notably low survival rate. To facilitate the transition from research to clinical use, Singla has partnered with Chakri Toleti, a healthcare technology entrepreneur, to form Exomic, a company dedicated to advancing this technology through funding and development. This collaboration exemplifies UCF's commitment to fostering innovation and translating academic research into impactful medical solutions. With ongoing support, the team aims to initiate FDA clinical trials, potentially revolutionizing treatment for millions suffering from these diseases.
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This innovative therapy could significantly improve treatment outcomes for cancer and heart disease patients, potentially reducing the side effects associated with traditional therapies.
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