The collapse of US-Iran negotiations in Islamabad on April 11-12 was anticipated due to stark differences in their positions. Iran, led by Assembly Speaker Mohammad Bagher Ghalibaf and Foreign Minister Abbas Araghchi, sought a comprehensive deal including ceasefire agreements and sanctions relief. Conversely, the US delegation, led by Vice President JD Vance, aimed for a narrower focus on nuclear program rollback and control of enriched uranium. The deep trust deficit, exacerbated by past experiences with the Joint Comprehensive Plan of Action (JCPOA), hindered progress. Following the talks, both sides issued statements reflecting their positions, with Vance emphasizing the need for Iran to commit to not pursuing nuclear weapons, while Ghalibaf criticized US demands as unreasonable. The failure of these talks raises concerns about escalating tensions, particularly in the strategic Strait of Hormuz, which could impact global energy markets. Despite the setback, there remains a possibility for future negotiations, albeit with significant political costs for both sides. The situation continues to evolve, with external influences from countries like China and Russia and India's interests in regional stability.