High-level negotiations between the United States and Iran are scheduled to take place on April 9-10, 2026, in Islamabad, Pakistan, following a ceasefire agreement. The talks come after significant tensions escalated due to the US's killing of Iran’s Supreme Leader Ayatollah Ali Khamenei on February 28, which triggered widespread conflict across the Middle East, including Israeli attacks on Iran and Hezbollah in Lebanon. However, Iranian news agency Fars reported that talks may be suspended if Israeli attacks on Lebanon continue. The US delegation will be led by Vice President JD Vance, accompanied by senior envoy Steve Witkoff and Jared Kushner. Iran's participation, led by Parliament Speaker Mohammad Bagher Ghalibaf and Foreign Minister Abbas Araghchi, remains uncertain, contingent on the cessation of hostilities. The agenda for the talks includes addressing the fragile ceasefire and Iran's nuclear program, with the US claiming Iran is willing to surrender its enriched uranium stock, a point that remains contentious. The negotiations are expected to take place at the Serena Hotel in Islamabad, with public holidays declared in Pakistan to accommodate the event.