Dr. Michael Yafi, a paediatric endocrinologist at the University of Texas Houston, presented intriguing findings at the European Congress on Obesity in Istanbul, suggesting that the subject of Leonardo da Vinci's iconic painting, the Mona Lisa, may have been overweight and possibly suffered from hypothyroidism. Yafi's research highlights a historical perspective where obesity was often viewed positively, particularly among women, contrasting sharply with contemporary ideals that favor thinness. He noted that the Mona Lisa, believed to be Lisa Gherardini, may have had high cholesterol or an underactive thyroid, conditions that could explain her depicted physique. Furthermore, Yafi pointed out that many historical figures, including composers Bach and Handel, were often portrayed as overweight, hinting at their potential health issues. Looking ahead, he speculated that future artworks might reflect modern beauty standards influenced by appetite-suppressing medications, leading to representations of women with gaunt features, termed 'GLP-1 face.' This evolving depiction of beauty can be traced back to ancient symbols of fertility, such as the Venus of Willendorf, which celebrated body positivity and abundance.