New Ebola Vaccines Under Development Amid Ongoing Outbreak
Three new Ebola vaccines are being developed. An infectious disease expert explains
The Conversation
Image: The Conversation
Recent funding of up to $62 million aims to expedite the development of three new Ebola vaccines targeting the Bundibugyo virus in the Democratic Republic of the Congo and Uganda. Current vaccines are ineffective against this strain, highlighting the urgent need for new solutions.
- 01The Coalition for Epidemic Preparedness Innovations has allocated up to $62 million for developing vaccines against the Bundibugyo Ebola virus.
- 02Three vaccine candidates are being developed: one by the International AIDS Vaccine Initiative, another by Moderna, and a third by the University of Oxford.
- 03Existing Ebola vaccines are effective only against the Zaire virus, not the Bundibugyo strain currently circulating.
- 04Clinical trials for these new vaccines are expected to begin within the next few months, with varying timelines for each candidate.
- 05Challenges in vaccine development include safety testing, regulatory approvals, and logistical issues in affected regions.
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In response to the ongoing Ebola outbreak in the Democratic Republic of the Congo (DRC) and Uganda, new funding of up to $62 million has been announced to accelerate the development of three vaccine candidates targeting the Bundibugyo virus. Current vaccines, Ervebo and Zabdeno/Mvabea, are effective only against the Zaire strain, necessitating the urgent need for new solutions. The three candidates include a single-dose vaccine from the International AIDS Vaccine Initiative, an mRNA-based vaccine from Moderna, and a candidate from the University of Oxford. While the WHO expert panel has identified the IAVI vaccine as the most promising, all candidates are still in various stages of development and testing. Clinical trials are anticipated to commence within the next few months, although significant challenges remain, including ensuring safety, regulatory approval, and logistical hurdles in the affected regions. Until a new vaccine is available, basic infection control measures will remain critical in managing the outbreak.
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The development of new vaccines could significantly enhance the ability to control the current Ebola outbreak and future occurrences.
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