Scientists Resurrect Rat Chromosome in Mice, Paving Way for De-Extinction Efforts
A chromosome from a frozen rat has been resurrected inside mice

Image: Newscientist
Researchers successfully transferred a chromosome from a frozen rat into living mouse cells, creating mice with added rat chromosomes. This technique may enable the study of extinct species' genes and aid conservation efforts, particularly for species like the Hawaiian poʻouli bird, which requires chromosome transfer for revival.
- 01Colossal Biosciences may face competition as researchers transfer a chromosome from a frozen rat into mouse cells.
- 02The technique allows for the creation of chimeric mice with some cells containing the rat chromosome, visible under UV light.
- 03The immediate goal is to study genes from extinct species, potentially aiding conservation efforts.
- 04Wakayama's team plans to test the technique on elephant cells and has obtained frozen elephant tissue for research.
- 05The revival of the Hawaiian poʻouli bird, which requires chromosome transfer, highlights the potential applications of this research.
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A team of scientists led by Teruhiko Wakayama at Yamanashi University in Japan has successfully transferred a chromosome from a rat that had been frozen for over a year into living mouse cells, creating chimeric mice with some cells containing the added chromosome. This breakthrough could significantly advance de-extinction efforts, particularly for species like the Hawaiian poʻouli bird that requires chromosome transfer for revival. The researchers aim to refine their technique further and apply it to elephant cells, potentially leading to the introduction of mammoth chromosomes into living cells. The process involves injecting a cell's nucleus into an egg to trigger chromosome condensation, followed by the extraction and injection of a single chromosome into another egg. While the current technique works only with rat chromosome 9, the team is exploring methods to improve success rates. The research opens new avenues for studying genes from extinct species, which could enhance conservation strategies and provide insights into genetic activity.
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The research could lead to breakthroughs in conservation biology and the revival of extinct species, impacting biodiversity efforts.
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