Yitzhak Apeloig, a distinguished Israeli scholar and former president of the Technion-Israel Institute of Technology, died at the age of 81. His tenure from 2001 to 2009 was marked by exceptional advancements in academic research and infrastructure, despite the turbulent socio-political climate in Israel. Under his leadership, the Technion saw the establishment of new research centers and a significant increase in international collaborations. Apeloig was recognized as a pioneer in computational chemistry, particularly in using quantum theory to predict molecular properties and in the chemistry of organosilicon compounds. His accolades include membership in the American Academy of Arts and Sciences and the Humboldt Prize. Born in Uzbekistan and emigrating to Israel as a child, Apeloig served in the IDF during the Yom Kippur War and later joined the Technion faculty in 1976. His presidency not only expanded research funding but also promoted inclusivity within the institution, integrating diverse populations into the academic community. Technion President Prof. Uri Sivan praised Apeloig's quiet confidence and impactful leadership.