During the second edition of the International Conference on Spacecraft Mission Operations (SMOPS), Dr. V Narayanan, Chairman of the Indian Space Research Organisation (ISRO), highlighted the evolution of artificial intelligence (AI) and machine learning from theoretical concepts to vital elements in space missions. He stated that these technologies are crucial for enhancing mission operations, particularly in achieving human-machine synergy. The conference, themed 'Innovative Operations for Smart and Sustainable Space Mission Management – Next Generation', will cover various topics including mission design, automation, and interplanetary exploration. Notably, ISRO's successful Chandrayaan 3 mission, which landed on the moon on August 23, 2023, showcased the effective application of AI and machine learning technologies, enabling autonomous operations through advanced sensors and cameras. As ISRO prepares for its upcoming uncrewed crew module missions related to the Gaganyaan program, the significance of mission operations, which extend well beyond the initial launch phase, was underscored. The conference brings together domain experts from esteemed organizations such as NASA, the European Space Agency (ESA), and the Japan Aerospace Exploration Agency (JAXA) to discuss advancements in space technology.