Iran's First Vice President Mohammad Reza Aref stated that a deal with the United States is possible if negotiations focus on 'America First' rather than 'Israel First.' This statement comes as high-profile ceasefire talks are set to begin in Islamabad, Pakistan, aimed at resolving the ongoing conflict in West Asia. An Iranian delegation, led by Mohammad-Bagher Ghalibaf, has arrived, while the US side is represented by Vice President JD Vance, accompanied by Jared Kushner and special envoy Steve Witkoff. Aref warned that if negotiations involve representatives of 'Israel First,' Iran would abandon any potential agreement and escalate its defense efforts. The conflict has already resulted in over 3,000 deaths in Iran, and the US insists on preventing Iran from acquiring nuclear weapons. As the two sides prepare for indirect talks, key issues remain unresolved, particularly regarding Israeli actions in Lebanon. The situation continues to pose risks for regional stability and international relations.