On April 2, 2024, the Central Pollution Control Board (CPCB) submitted findings to the National Green Tribunal (NGT) advising against the use of bio-enzymes, including Draynzyme, for cleaning natural water bodies like rivers and lakes. The CPCB's report highlighted ecological concerns and the absence of adequate scientific evidence supporting the long-term environmental safety of such substances. This issue arose from a suo moto case initiated by the NGT following a report by Hindustan Times, which revealed that the Pune Municipal Corporation (PMC) had used bio-enzymes without proper approvals. The PMC had applied Draynzyme on a trial basis to combat water hyacinth in a small area of stagnant water along the Ramnadi river. While the product is claimed to aid in breaking down organic waste, the CPCB noted that its application in natural ecosystems lacks sufficient scientific validation regarding dosage, long-term impacts, and behavior in complex aquatic environments. Although short-term toxicity studies showed no immediate harm to aquatic life, experts expressed concerns about potential long-term risks, such as bioaccumulation. The CPCB concluded that Draynzyme is unsuitable for river cleaning or lake restoration but may be used in sewage drains under strict monitoring to prevent additional pollution to natural water bodies.