The enmity between the United States and Iran dates back to the 1979 Islamic Revolution, which included the hostage crisis at the US embassy in Tehran. This event led to the severing of diplomatic relations and the imposition of sanctions by the US. Over the years, the US has accused Iran of supporting terrorism and pursuing nuclear weapons, culminating in President Donald Trump's 2018 withdrawal from the nuclear deal, which had aimed to limit Iran's nuclear capabilities. This withdrawal prompted Iran to begin rolling back its commitments under the agreement. The situation escalated further with the assassination of Iranian general Qasem Soleimani in January 2020 and subsequent military actions, including the bombing of Iranian nuclear sites in 2025. As of April 2026, the two countries have entered into high-level talks in Islamabad, Pakistan, to address ongoing conflicts following a fragile ceasefire, with both sides expressing deep mistrust. The outcome of these talks is critical, as the ceasefire is set to expire on April 22, 2026, unless an agreement is reached.