Semaglutide and tirzepatide are gaining popularity as weight loss solutions, especially with their increasing accessibility due to generic versions entering the market. However, Dr. G. Nasiruddin, a consultant in internal medicine at Fortis Hospital in Bengaluru, India, warns that this trend may lead to a rise in self-medication, which can be dangerous without medical supervision. These prescription drugs are not meant for everyone and should only be used under careful evaluation based on specific medical criteria such as Body Mass Index (BMI) and the presence of type 2 diabetes. Misuse can lead to serious side effects, including nausea, vomiting, and even pancreatitis, particularly in individuals with pre-existing health conditions. Dr. Nasiruddin stresses that these medications should not be viewed as shortcuts for cosmetic weight loss but as part of a comprehensive treatment plan for obesity-related health issues. When used correctly, they can improve quality of life and long-term health outcomes. Ultimately, the message is clear: a proper medical consultation is essential to ensure safe and effective use of these powerful medications.