A recent study conducted by the neurosurgery department at the Post Graduate Institute of Medical Education and Research in Chandigarh, India, has demonstrated that minimally invasive keyhole brain surgery leads to significantly less inflammatory response compared to traditional open neurosurgery. Published on March 24, 2026, in the international journal 'Neurosurgical Review', this research is notable as it is the first of its kind to compare these surgical techniques in the global medical literature. The study, led by Dr. SS Dhandapani and Dr. Hemant Bhagat, analyzed inflammatory markers such as C-reactive protein (CRP) and Caspase-3 in 40 patients who underwent keyhole surgery versus 150 patients who had open surgery. The findings suggest that keyhole surgery not only results in lesser inflammation but also offers long-term benefits, including a reduced risk of post-operative seizures and cognitive deficits. Additionally, this minimally invasive approach is associated with less pain, fewer side effects, and improved cosmetic outcomes due to smaller incisions, enhancing the overall quality of life for patients.