Recently, Singapore reported cases of Mpox involving a more serious clade 1b variant, raising global concerns. Mpox, caused by the monkeypox virus, spreads mainly through close human contact, including skin-to-skin contact and respiratory particles. Symptoms typically manifest as a rash, fever, headaches, and swollen lymph nodes, lasting between 2 to 4 weeks. Severe cases can lead to complications such as pneumonia and encephalitis, necessitating hospitalization. While there is no standard treatment, supportive care can help most recover, and the antiviral drug tecovirimat has been approved in some regions, although its effectiveness is still being evaluated. The World Health Organization indicates that the death rate for Mpox varies between 0.1% and 10%, influenced by healthcare access and underlying health conditions. Preventive measures, including regular cleaning and hand hygiene, are essential to mitigate the spread of the virus.