Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis that primarily impacts the spine and sacroiliac joints. If untreated, it can lead to the fusion of spinal bones, significantly reducing flexibility and mobility. Dr. Shrikant Dalal, a spine surgeon at Ruby Hall Clinic, emphasizes the importance of early diagnosis and multidisciplinary management, as AS affects 0.1 to 0.5 percent of the Indian population, particularly those aged 20 to 40. Initial symptoms, often mistaken for routine back pain, include persistent back pain, stiffness that improves with movement, and fatigue. Lifestyle changes such as regular physical activity, daily physiotherapy, and maintaining proper posture are crucial for managing AS. Treatment options include non-steroidal anti-inflammatory drugs (NSAIDs) and biologic therapies. In severe cases, surgical intervention may be required. Recognizing symptoms early and seeking appropriate care can help maintain mobility and prevent permanent spinal damage.