An outbreak of H5N1 avian influenza has been confirmed in Mathkuru village, located in Hesaraghatta, Karnataka, following a report from the National Institute of High Security Animal Diseases dated April 14. In response, authorities have initiated containment measures, including the culling of 7,444 birds, 14,788 eggs, and 2,250 kg of poultry feed on April 15. Mathkuru has been declared an infected zone with a radius of 0-3 km, while the surrounding 3-10 km area is under surveillance. The local health department has mobilized teams to conduct daily fever surveillance in the affected villages, which include a total population of 25,817. Ten individuals involved in the culling process have been quarantined and are under medical supervision. The public is advised to avoid contact with sick or dead birds and to report any such cases to local authorities, while consumption of properly cooked poultry products remains safe.