The National Multiple Sclerosis Society, in collaboration with Prisma Health and the Medical University of South Carolina (MUSC), is making significant progress in improving access to multiple sclerosis (MS) care in South Carolina. Currently, individuals with MS in the state travel an average of 66 miles to receive specialty care, which can delay diagnosis and treatment. The MS Care Desert Initiative, supported by a historic sponsorship from Genentech, aims to bridge these care gaps. Since the initiative's launch, MUSC has increased referrals to the MS Navigator program from just one to 270, showcasing the effectiveness of improved referral pathways. Additionally, Prisma Health has initiated the first neurospecialized MS rehabilitation program in the Midlands, significantly increasing the number of patients receiving rehabilitation services. The South Carolina Community Health Worker Association is also developing MS-specific training to enhance culturally responsive care. This pilot program is part of a larger initiative addressing MS care gaps in multiple states, with the goal of ensuring timely and effective treatment for the estimated 14,800 people living with MS in South Carolina.