Justin Chambers' exit from Grey's Anatomy as Alex Karev has become one of the most controversial moments in the show's history. His departure, announced in January 2020, followed a storyline that many fans found uncharacteristic for Alex, who had evolved from a disliked intern to a trusted pediatric surgeon. The way he left—choosing to reunite with Izzie instead of confronting Jo directly—left viewers divided, feeling it undermined his character's growth. Chambers stated he wanted to diversify his acting career after 15 years on the show, thanking the cast and crew, including creator Shonda Rhimes. Following his departure, he appeared in The Offer, portraying Marlon Brando, and in Accused, where he played a character reminiscent of his earlier role. Although rumors about a potential return to Grey's Anatomy have circulated, Chambers has indicated he is focused on new projects, making his return uncertain. The complexity of Alex's exit, particularly its implications for Jo, adds to the ongoing debate among fans about the character's legacy and potential future.