Incyte's Monjuvi Drug Combination Shows Promise in Blood Cancer Treatment Despite High Side Effects
Incyte Blood Cancer Drug Combo Reduces Disease-Progression Risk but With High Side-Effect Rate
Usnews
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Incyte's Monjuvi, combined with Revlimid and R-CHOP chemotherapy, decreased the risk of disease progression by 25% for patients with diffuse large B-cell lymphoma. However, the combination resulted in a higher rate of severe side effects and treatment discontinuations compared to standard care.
- 01The combination therapy reduced the risk of disease progression, relapse, or death by 25% compared to R-CHOP alone.
- 02Severe adverse events occurred in 87% of patients receiving the Monjuvi combo, compared to 76% for R-CHOP.
- 03Discontinuation of treatment due to adverse events was higher at 25.7% for the Monjuvi group versus 18% for standard care.
- 04The overall death rate was lower in the Monjuvi group at 18.5%, compared to 21.7% for R-CHOP.
- 05Incyte plans to seek expanded approval for the combination therapy as a first-line treatment for newly diagnosed patients.
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Incyte's blood cancer drug Monjuvi, when used in combination with Bristol Myers Squibb's Revlimid and the standard chemotherapy regimen R-CHOP, has shown a 25% reduction in the risk of disease progression, relapse, or death for patients with diffuse large B-cell lymphoma (DLBCL). However, this combination therapy is associated with a higher incidence of severe side effects, with nearly 87% of patients experiencing adverse events compared to 76% in those receiving R-CHOP alone. Additionally, 25.7% of patients on the Monjuvi regimen discontinued treatment due to adverse events, compared to 18% for standard care. The overall death rate was lower in the Monjuvi group at 18.5%, compared to 21.7% for R-CHOP. Incyte's research chief, Pablo Cagnoni, indicated that more comprehensive survival data will be available later. The company is also looking to expand the approval of this therapy for newly diagnosed patients, potentially doubling the eligible population for treatment.
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The findings could influence treatment protocols for DLBCL, potentially offering a new first-line therapy option.
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