As the NFL prepares for the 2026 Draft, the focus shifts to the players selected with the 45th overall pick from 2015 to 2025. This list features a mix of players who have made significant contributions to their teams and those who have struggled. Notably, Derrick Henry, drafted in 2016, has become one of the league's premier running backs, amassing 13,018 rushing yards and 127 touchdowns over his career. Antoine Winfield Jr., selected in 2020, has solidified his status as a top safety, earning two Pro Bowl selections. Brian Branch, a standout safety from the 2023 class, has already made a name for himself with 177 solo tackles and 7 interceptions. Other notable players include Edgerrin Cooper (2024) and JT Tuimoloau (2025), who are still in the early stages of their careers. This overview highlights the varying degrees of success among the 45th overall selections, reflecting the unpredictable nature of the NFL Draft.