In response to growing concerns over the safety of pediatric medicines, India's drug regulatory authority is drafting guidelines to regulate the use of high-risk solvents such as Propylene Glycol, Diethylene Glycol (DEG), and Ethylene Glycol (EG). This initiative follows several tragic incidents where contaminated cough syrups led to the deaths of children. The Drugs Consultative Committee (DCC) highlighted that many oral liquid formulations are currently manufactured with these solvents, which pose significant safety risks due to potential contamination. At its 67th meeting, the DCC suggested that the Central Drugs Standard Control Organization (CDSCO) engage with stakeholders to evaluate the situation and gather information on existing formulations. The urgency of this action is underscored by incidents involving cough syrups made in India, where at least 23 children died after consuming Coldrif syrup, which was found to contain DEG at levels exceeding permissible limits by 500 times. The DCC is also exploring the feasibility of using safer formulation alternatives.