U.S. health officials have issued quarantine orders for two passengers from a cruise ship experiencing a hantavirus outbreak. These individuals are currently hospitalized in Nebraska, where they are part of a group of 18 passengers being monitored until May 31. The orders, signed by Dr. Jay Bhattacharya, acting director of the Centers for Disease Control and Prevention (CDC), can be enforced with fines and prison time if individuals object to public health measures. Although there are no confirmed hantavirus cases among the passengers, symptoms can take up to 42 days to manifest, prompting the extended monitoring period. The CDC has identified three additional hantavirus cases in France, Spain, and Canada since the passengers disembarked. The World Health Organization reported a total of 11 cases linked to the cruise, including three deaths, with eight cases confirmed through laboratory tests. Hantaviruses typically spread through inhalation of contaminated rodent droppings, but the Andes virus may have rare human-to-human transmission. Public health officials maintain that the overall risk to the general public remains low.