Menopause marks a significant transition in a woman's life, characterized by a decline in estrogen levels, which can lead to various health issues, including increased susceptibility to neurological conditions like Parkinson's disease. Gynaecologist Dr. Lakshmi Aswathaman explains that estrogen has a protective role on dopamine-producing neurons, and its decline during menopause can exacerbate symptoms of Parkinson's disease, a progressive neurodegenerative disorder. Research indicates that women who undergo menopause later may have a reduced risk of developing Parkinson's due to longer exposure to natural estrogen. Hormone replacement therapy (HRT) has been found to potentially benefit certain Parkinson's symptoms, particularly in older individuals, by stabilizing proteins in the brain associated with neurological diseases. HRT may also help manage other menopause-related symptoms, including fatigue and mood disturbances, thus offering a complementary approach to managing Parkinson's disease in postmenopausal women.