Prostate cancer, a prevalent disease among men, is experiencing a transformation in diagnosis and treatment due to technological innovations. Traditional methods, primarily relying on PSA tests and biopsies, are being enhanced by advanced imaging, robotics, and artificial intelligence. Prof. David Margel from Assuta Ramat Hachayal highlights that the new Mona Lisa robotic system combines MRI and real-time ultrasound to create a detailed 3D model of the prostate, allowing for more accurate biopsy procedures. This system employs a transperineal approach, significantly reducing infection risks compared to traditional methods. In a study of 658 patients, no infections were reported with this new technique. Furthermore, the integration of artificial intelligence allows for real-time adjustments during the biopsy, improving precision. Beyond diagnostics, these advancements enable focal treatments that target only the tumor, preserving surrounding healthy tissue. This shift towards personalized medicine reflects a broader trend in healthcare, where treatment is tailored to individual patient needs based on precise diagnostic information. Overall, these innovations are not only enhancing the accuracy of prostate cancer management but also improving patient safety and quality of life.