Hepta's Blood Test Demonstrates Superior Efficacy in Identifying MASH Patients for Treatment
Hepta's Blood Test Outperforms FIB-4, ELF, and FibroScan in Identifying Treatment-Eligible MASH Patients

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Hepta's blood test has shown higher accuracy than FIB-4, ELF, and FibroScan in identifying treatment-eligible patients with metabolic dysfunction-associated steatohepatitis (MASH) with F2/F3 fibrosis. The findings will be presented at the EASL 2026 Congress in Barcelona, highlighting the test's potential to improve patient outcomes.
- 01The study involved 528 biopsy-confirmed MASH patients across three independent cohorts.
- 02Hepta's test achieved an AUC of 0.83 in detecting significant fibrosis (F2+) compared to existing non-invasive tests.
- 03The platform was validated on a separate cohort of 179 patients, ensuring robust results.
- 04Hepta's LiquidTransformer AI platform is designed to analyze cfDNA methylation patterns from blood samples.
- 05The findings support Hepta's goal of accurately identifying treatment-eligible patients and monitoring therapy responses.
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Hepta, a liquid biopsy company, has announced that its blood test significantly outperforms traditional non-invasive tests such as FIB-4, ELF, and FibroScan in identifying patients with metabolic dysfunction-associated steatohepatitis (MASH) who are eligible for treatment. The clinical data, derived from a study involving 528 biopsy-confirmed MASH patients, will be presented at the European Association for the Study of the Liver (EASL) 2026 Congress. The results indicate that Hepta's test, which utilizes cfDNA methylation analysis, achieved an area under the curve (AUC) of 0.83 in detecting significant fibrosis (F2+). This performance is crucial as existing tests often miss nearly one-third of patients who qualify for therapy. Hepta's LiquidTransformer platform, an AI model trained on extensive data, allows for a non-invasive approach to accurately assess disease biology, facilitating better treatment decisions. The findings underscore the potential for Hepta's blood test to transform the management of MASH, providing clinicians with a reliable tool to identify and monitor treatment-eligible patients effectively.
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The introduction of Hepta's blood test could significantly improve the identification of MASH patients eligible for treatment, enhancing patient care.
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