Collagen supplements have gained popularity for their potential benefits in enhancing skin tone and texture and alleviating joint pain. A comprehensive meta-analysis published in the Aesthetic Surgery Journal reviewed 113 randomized controlled trials involving nearly 8,000 participants. It concluded that collagen supplementation positively affects skin elasticity and hydration, musculoskeletal health, and osteoarthritis management, though results for oral health and cardiometabolic factors were less convincing. Collagen, the body's most abundant protein, is produced by fibroblasts, but its production declines with age and due to factors like sun damage and smoking. Experts suggest that while collagen supplements may not directly increase collagen levels, they provide the body with necessary building blocks to synthesize new collagen. Hydrolyzed collagen is particularly effective for skin health, while undenatured type II collagen may help reduce joint pain. Although collagen is not a cure, it may slow osteoarthritis progression and improve joint function. Consulting with a healthcare provider before starting supplementation is recommended, as results may take time.