Claudia Andl, an Associate Professor at the UCF College of Medicine, is investigating the potential of a simple probiotic, Lactobacillus spp., to treat acid reflux and prevent esophageal cancer. Acid reflux, characterized by symptoms such as heartburn and chest pain, can lead to serious complications, including Barrett's esophagus and esophageal cancer, which has a low five-year survival rate of about 22%. Funded by a grant of over $380,000 from the Florida Department of Health's Florida Cancer Innovation Fund, Andl's research focuses on how probiotics can restore the microbial environment of the esophagus, suppress inflammation, and repair DNA damage caused by stomach acid. Initial findings suggest that Lactobacillus spp. may reduce the incidence of Barrett's esophagus and delay cancer development. Andl emphasizes the importance of maintaining a healthy bacterial balance in the esophagus, similar to gut health, as the prevalence of Barrett's esophagus and esophageal cancer is increasing, particularly among younger patients. The research aims to inform new therapies and improve outcomes for patients at risk.