In the second T20I match at Kingsmead, Durban, South Africa won the toss and opted to bowl first against India. Captain Laura Wolvaardt expressed confidence in her team's ability to chase, anticipating a slower pitch than in the first match. This game is significant for India as it marks Shafali Verma's 100th T20I appearance. India made two changes to their lineup, introducing Anushka Sharma, who is making her international debut after a strong performance in the Women's Premier League, and Kranti Goud. They replaced Kashvee Gautam and Renuka Singh, who were benched after the team's previous performance. The South African squad remains unchanged, with Wolvaardt and Sune Luus opening the batting. Following this match, the series will move to the Highveld, with matches three and four scheduled at the Wanderers and the finale in Benoni.