The San Diego Padres will host the Chicago Cubs at Petco Park on April 27, 2026, in the tenth series of the MLB season. The Padres recently split a series with the Arizona Diamondbacks, while the Cubs are coming off a loss to the Los Angeles Dodgers. The Padres are favored with a money line of -115 compared to the Cubs' -105. Starting for the Padres is Randy Vasquez, who boasts a 2-0 record with a 1.88 ERA, while the Cubs will send veteran Matthew Boyd to the mound, who has a 1-1 record and a 5.79 ERA. The predicted score for the game is 5-3 in favor of the Padres. Bettors might find value in taking the Padres on the run line at -1.5 (+171) and the total runs over 7.5 (-115). Key players to potentially hit home runs include Fernando Tatis Jr. and Ian Happ.