Matteo Berrettini is set to compete in the quarterfinals of the French Open for the first time since 2021, facing fellow Italian Matteo Arnaldi on Wednesday. Berrettini, 30, has struggled with injuries in recent years, but he has regained form at Roland Garros, defeating Juan Manuel Cerundolo in straight sets in the fourth round. He is favored to win with odds of -185, as he seeks to reach a Grand Slam final for the first time since Wimbledon in 2021. In contrast, Arnaldi, 24, has had a breakout tournament, reaching the quarterfinals after defeating No. 19 Frances Tiafoe in a grueling five-set match. This will be their first encounter, and while Arnaldi has shown resilience, Berrettini's experience and strong clay court performance (71-31 career record) suggest he may have the upper hand. The match is scheduled for June 3 at 2:15 p.m. EST, broadcast on truTV/TNT/HBO Max.