The 12th live summit of the Indo Japanese CTO Club, inaugurated by A.B. Mehta, senior interventional cardiologist at Jaslok Hospital in Mumbai, focuses on advancements in catheter-based coronary interventions. Experts highlighted how these innovations allow for successful treatment of Chronic Total Occlusions (CTO) in patients previously deemed unsuitable for intervention. The summit features live transmissions of 15 complex coronary interventions from leading cardiac centers across India, Japan, Europe, and the United States. Key discussions revolve around contemporary strategies for managing complex coronary blockages, including advanced guidewire techniques and imaging-guided interventions. Special sessions will address challenging patient groups, such as those with severe heart failure and chronic kidney disease. With over 800 cardiologists, interventional specialists, fellows, and trainees participating, the summit aims to enhance knowledge and skills in managing difficult coronary interventions. The event will conclude on Sunday, June 6, 2026, marking a significant gathering for the advancement of cardiac care.