In a recent podcast appearance on Good Hang With Amy Poehler, Kim Kardashian (reality TV star and entrepreneur) shared her experience of taking 35 supplements daily, which has resulted in what she describes as 'pill fatigue.' This fatigue refers to the mental and physical exhaustion that can occur when managing a high volume of medications or supplements. Kardashian mentioned that she spreads her supplement intake across three daily doses but has found it increasingly burdensome. She humorously expressed a wish for an IV drip to simplify her routine.

While 'pill fatigue' is not an officially recognized medical condition, it is commonly understood among healthcare professionals as the emotional and physical toll associated with taking multiple medications over time. This can lead to skipped doses or even discontinuation of medications without consulting a doctor, negatively affecting health outcomes, especially for those with chronic conditions like diabetes or heart disease. Experts recommend strategies to manage this fatigue, such as evaluating the necessity of each supplement, using medication organizers, and opting for combination medications when possible.